The ̄avonoids of Tanacetum parthenium and T. vulgare and their anti-in ̄ammatory properties
نویسندگان
چکیده
The lipophilic ̄avonoids in leaf and ̄ower of Tanacetum parthenium and T. vulgaris have been compared. While those of T. parthenium are methyl ethers of the ̄avonols 6-hydroxykaempferol and quercetagetin, the surface ̄avonoids of T. vulgare are methyl ethers of the ̄avones scutellarein and 6-hydroxyluteolin. Apigenin and two ̄avone glucuronides are surprisingly present in glandular trichomes on the lower epidermis of the ray ̄orets of T. parthenium. The opportunity has been taken to revise the structures of the four 6-hydroxy ̄avonol methyl ethers of T. parthenium based on NMR measurements. These are now shown to be uniformly 6rather than 7-O-methylated. Tanetin, previously thought to be a new structure, is now formulated as the known 6-hydroxykaempferol 3,6,4 '-trimethyl ether. The vacuolar ̄avonoids of both plants are dominated by the presence of apigenin and luteolin 7-glucuronides; nine other glycosides were present, including the uncommon 6-hydroxyluteolin 7-glucoside in T. vulgare. When the major ̄avonol and ̄avone methyl ethers of the two plants were tested pharmacologically, they variously inhibited the major pathways of arachidonate metabolism in leukocytes. There were signi®cant dierences in potency, with the tansy 6-hydroxy ̄avones less active than the feverfew 6-hydroxy ̄avonols as inhibitors of cyclo-oxygenase and 5-lipoxygenase. # 1999 Elsevier Science Ltd. All rights reserved.
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